Microbial and metabolic multi-omic correlations in systemic sclerosis patients
Metadatos
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Bellocchi, Chiara; Fernández Ochoa, Álvaro; Montanelli, Gaia; Vigone, Barbara; Santaniello, Alessandro; Milani, Christian; Quirantes-Piné, Rosa; Borras Linares, María Isabel; Ventura, Marco; Segura-Carrettero, Antonio; Alarcón Riquelme, Marta Eugenia; Beretta, LorenzoEditorial
Wiley Periodicals Inc. on behalf of The New York Academy of Sciences
Materia
Systemic sclerosis Microbiota Metabolome Gastrointestinal
Fecha
2018Referencia bibliográfica
Nombre(s), p.ej. Manuel Bellocchi, Chiara; Fernández-Ochoa, Álvaro; Montanelli, Gaia; Vigone, Barbara; Santaniello, Alessandro; Milani, Christian; Quirantes-Piné, Rosa; Borrás-Linares, Isabel; Ventura, Marco; Segura-Carrettero, Antonio; Alarcón Riquelme, Marta Eugenia; Beretta, Lorenzo. Microbial and metabolic multi-omic correlations in systemic sclerosis patients. Ann. N.Y. Acad. Sci. 1421 (2018) 97–109. [http://hdl.handle.net/10481/54802]
Patrocinador
This work was supported by EU/EFPIA/Innovative Medicines Initiative Joint Undertaking PRECISESADS grant No. 115565.Resumen
Intestinal microbiota has been associated with systemic autoimmune diseases, yet the functional consequences of
these associations are elusive.We characterized the fecal microbiota (16S rRNA gene amplification and sequencing)
and the plasma metabolome (high-performance liquid chromatography coupled to mass spectrometry) in 59 patients
with systemic sclerosis (SSc) and 28 healthy controls (HCs).Microbial and metabolic data were cross-correlated to find
meaningful associations after extensive data mining analysis and internal validation. Our data show that a reduced
model of nine bacteria is capable of differentiating HCs from SSc patients. SSc gut microbiota is characterized
by a reduction in protective butyrate-producing bacteria and by an increase in proinflammatory noxious genera,
especially Desulfovibrio. From the metabolic point of view, a multivariate model with 17 metabolite intermediates
well distinguished cases from controls. The most interesting peaks we found were identified as glycerophospholipid
metabolites and benzene derivatives. The microbial and metabolic data showed significant interactions between
Desulfovibrio and alpha-N-phenylacetyl-l-glutamine and 2,4-dinitrobenzenesulfonic acid. Our data suggest that in
SSc, intestinal microbiota is characterized by proinflammatory alterations subtly entwined with the metabolic state.
Desulfovibrio is a relevant actor in gut dysbiosis that may promote intestinal damage and influence amino acid
metabolism.