Effects of hydroxytyrosol dose on the redox status of exercised rats: the role of hydroxytyrosol in exercise performance
Metadatos
Mostrar el registro completo del ítemAutor
Al Fazazi, Saad; Casuso, Rafael A.; Aragón Vela, Jerónimo; Casals Vázquez, Cristina; Rodríguez Huertas, Jesús FranciscoEditorial
BioMed Central
Materia
Polyphenols ROS Exercise Hemoglobin Oxidative stress Antioxidants
Fecha
2018-04-27Referencia bibliográfica
Al Fazazi et al. Effects of hydroxytyrosol dose on the redox status of exercised rats: the role of hydroxytyrosol in exercise performance. Journal of the International Society of Sports Nutrition (2018) 15:20 [ http://hdl.handle.net/10481/53635]
Patrocinador
This study was supported by the grant #3650 managed by Fundación General Empresa-Universidad de Granada, and by the investigation group CTS-454 “Impacto fisiológico del estrés oxidativo, deporte, actividad física y salud”Resumen
Background: Hydroxytyrosol (HT) is a polyphenol found in olive oil that is known for its antioxidant effects. Here,
we aimed to describe the effects of a low and high HT dose on the physical running capacity and redox state in
both sedentary and exercised rats.
Methods: Male Wistar rats were allocated into 6 groups: sedentary (SED; n = 10); SED consuming 20 mg/kg/d HT
(SED20; n = 7); SED consuming 300 mg/kg/d HT (SED300; n = 7); exercised (EXE; n = 10); EXE consuming 20 mg/kg/d
HT (EXE20; n = 10) and EXE consuming 300 mg/kg/d HT (EXE300; n = 10). All the interventions lasted 10 weeks; the
maximal running velocity was assessed throughout the study, whereas daily physical work was monitored during
each training session. At the end of the study, the rats were sacrificed by bleeding. Hemoglobin (HGB) and
hematocrit (HCT) were measured in the terminal blood sample. Moreover, plasma hydroperoxide (HPx)
concentrations were quantified as markers of lipid peroxidation.
Results: In sedentary rats, HT induced an antioxidant effect in a dose-dependent manner without implications on
running performance. However, if combined with exercise, the 300 mg/kg/d HT dosage exhibited a pro-oxidant
effect in the EXE300 group compared with the EXE and EXE20 groups. The EXE20 rats showed a reduction in daily
physical work and a lower maximal velocity than the EXE and EXE300 rats. The higher physical capacity exhibited
by the EXE300 group was achieved despite the EXE300 rats expressing lower HGB levels and a lower HCT than the
EXE20 rats.
Conclusions: Our results suggest that a high HT dose induces a systemic pro-oxidant effect and may prevent the
loss of performance that was observed with the low HT dose.