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dc.contributor.authorVarela López, Alfonso es_ES
dc.contributor.authorOchoa Herrera, Julio José es_ES
dc.contributor.authorLlamas Elvira, José Manuel es_ES
dc.contributor.authorLópez Frías, Magdalena es_ES
dc.contributor.authorPlanells Del Pozo, Elena María es_ES
dc.contributor.authorRamírez Tortosa, María Carmen es_ES
dc.contributor.authorRamírez Tortosa, César Luis es_ES
dc.contributor.authorGiampieri, Francescaes_ES
dc.contributor.authorBattino, Maurizioes_ES
dc.contributor.authorQuiles Morales, José Luis es_ES
dc.identifier.citationVarela-López, A.; et al. Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition. Nutrients, 9(2): 176 (2017). []es_ES
dc.description.abstractDuring aging, bone mass declines increasing osteoporosis and fracture risks. Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained for 6 or 24 months on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10), to evaluate the potential of adding this molecule to the n-3 polyunsaturated fatty acid (n-3 PUFA)-based diet for bone mineral density (BMD) preservation. BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin, parathyroid hormone, urinary F2-isoprostanes, and lymphocytes DNA strand breaks were also measured. BMD was lower in aged rats fed a diet without CoQ10 respect than their younger counterparts, whereas older animals receiving CoQ10 showed the highest BMD. F2-isoprostanes and DNA strand breaks showed that oxidative stress was higher during aging. Supplementation with CoQ10 prevented oxidative damage to lipid and DNA, in young and old animals, respectively. Reduced oxidative stress associated to CoQ10 supplementation of this n-3 PUFA-rich diet might explain the higher BMD found in aged rats in this group of animals.en_EN
dc.description.sponsorshipThis work was supported by the Spanish Ministry of Education and Science (AGL2008-01057) and the Autonomous Government of Andalusia (AGR832). A.V.-L. is recipient of a grant for doctors from University of Granada’s own plan.en_EN
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.subjectAntioxidants en_EN
dc.subjectDietary faten_EN
dc.subjectN-3 PUFAen_EN
dc.subjectOxidative stress en_EN
dc.titleAge-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Additionen_EN

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