Vinyl sulfone: a multi-purpose function in proteomics

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URI: http://hdl.handle.net/10481/29649
ISBN: 978-953-51-0070-6
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Autor
López Jaramillo, Francisco Javier; Hernández Mateo, Fernando; Santoyo González, Francisco
Editorial
Intech
Materia
Vinyl sulfone
 
Proteomics
 
Chemistry
 
Synthesis
 
Fecha
2012
Referencia bibliográfica
López Jaramillo, F.J.; Hernández Mateo, F.; Santoyo González, F. Vinyl sulfone: a multi-purpose function in proteomics. In: Eastwood Leung, H.-C. (ed.), Integrative proteomics. Rijeka (Croatia): Intech, 2012. pp. 301- 326. [http://hdl.handle.net/10481/29649]
Patrocinador
The authors acknowledge Dirección General de Investigación Científica y Técnica (DGICYT) (CTQ2008-01754) and Junta de Andalucía (P07-FQM-02899) for financial support.
Resumen
The chapter is organized in three sections. In a first instance, a general overview of the vinyl sulfone chemistry in terms of the most relevant methods of synthesis and aspects of their reactivity will be followed by a discussion of the application of this chemical behaviour with proteins. Their advantages and disadvantages with other currently available methodologies to modify amine and thiol groups naturally present in proteins will be compared. In a second section the applications of vinyl sulfones to Proteomics will be enumerated. Finally, the wide scope of the vinyl sulfone chemistry in other omic sciences will be discussed.
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