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dc.contributor.authorMegía Fernández, Alicia 
dc.contributor.authorHernández Mateo, Fernando 
dc.contributor.authorSantoyo González, Francisco 
dc.date.accessioned2013-12-04T07:56:18Z
dc.date.available2013-12-04T07:56:18Z
dc.date.issued2013
dc.identifier.citationMegía-Fernández, A.; Hernández-Mateo, F.; Santoyo-González, F. Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation. Organic and Biomolecular Chemistry 11(16): 2586-2596 (2013). [http://hdl.handle.net/10481/29536]es_ES
dc.identifier.issn1477-0520
dc.identifier.issn1477-0539
dc.identifier.otherdoi: 10.1039/C3OB27209E
dc.identifier.urihttp://hdl.handle.net/10481/29536
dc.description.abstractThe easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocene–cyclodextrin, ferrocene–peptide and ferrocene–protein conjugates).es_ES
dc.description.sponsorshipFinancial support was provided by Ministerio de Ciencia e Innovación (CTQ2011-29299-CO2-01).es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society Chemistryes_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectVinyl sulfonees_ES
dc.subjectFerrocenees_ES
dc.subjectSynthesis es_ES
dc.titleVinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugationes_ES
dc.typejournal articlees_ES
dc.rights.accessRightsopen accesses_ES


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