Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation
Metadatos
Afficher la notice complèteEditorial
Royal Society Chemistry
Materia
Vinyl sulfone Ferrocene Synthesis
Date
2013Referencia bibliográfica
Megía-Fernández, A.; Hernández-Mateo, F.; Santoyo-González, F. Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation. Organic and Biomolecular Chemistry 11(16): 2586-2596 (2013). [http://hdl.handle.net/10481/29536]
Patrocinador
Financial support was provided by Ministerio de Ciencia e Innovación (CTQ2011-29299-CO2-01).Résumé
The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocene–cyclodextrin, ferrocene–peptide and ferrocene–protein conjugates).