Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

Abstract

N.G.­B. is supported by an American Diabetes Association postdoctoral fellowship (1­18­PMF­032). J.S.G. was supported by an MGH NIH T32 Training Grant (HL007208), the John S. LaDue Memorial Fellowship and the MGH Physician Scientist Development Program. This work was supported by a Weill Cornell Department of Medicine Seed Grant for Innovative Research to J.C.L., the JPB Foundation (to B.M.S.), Jill Roberts IBD Institute (to G.P.) and NIH grants DK097303 (to J.C.L.), R03 DK111762 (to J.C.L.), R01 DK121844 (to J.C.L.), R01 HL140224 (to J.E.H.) and R01 HL134893 (to J.E.H.). This work was partially supported by the National Heart, Lung and Blood Institute’s Framingham Heart Study (contracts N01­HC­25195 and HHSN268201500001I) and by the Division of Intramural Research (to P.C., G.S., C.L., S.­J.H. and D.L.) of the National Heart, Lung and Blood Institute. We acknowledge support from the Yale Mouse Metabolic Phenotyping Center via NIH grants nos. U24 DK­059635, R01 DK116774, R01 DK114793 and P30 DK045735 (all to G.I.S.).