Metal-dependent Glycosylation in Recombinant Metallothioneins
Metadatos
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García Risco, Mario; González Garnica, Ana Isabel; Calatayud, Sara; López Jaramillo, Francisco Javier; Pedrini Martha, Veronika; Albalat, Ricard; Dallinger, Reinhard; Domínguez Vera, José Manuel; Palacios, Óscar; Capdevila, MercèEditorial
Royal Society of Chemistry
Fecha
2022-11-15Referencia bibliográfica
Published version: García Risco, Mario et al. Metal-dependent Glycosylation in Recombinant Metallothioneins. Chem. Commun., 2022,58, 13755-13758. https://doi.org/10.1039/D2CC05589A
Patrocinador
Spanish Ministerio de Ciencia e Innovación; FEDER: BIO2015-67358-C2-2-P, PID2021-123258NB-I00, PID2019-111461GB-I00; Austrian Science Fund I 3032-B21; Generalitat de Catalunya 2017SGR-864, 2017SGR-1665; Junta de Andalucía PAIDI 2020 program (DOC_00791); Universitat Autònoma de Barcelona (ICP-AES, ESI-MS); University of InnsbruckResumen
We show for the first time glycosylation of recombinant metallothioneins (MTs) produced in E. coli. Interestingly, our results show that the glycosylation level of the recombinant MTs is inversely proportional to the degree of protein structuration, and reflects their different metal preferences.