Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with Fibromyalgia
Metadatos
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Aguilar Ferrandiz, María Encarnación; Casas Barragán, Antonio; Tapia-Haro, Rosa María; Rus Martínez, María del Alma; Molina, Francisco; Correa-Rodríguez, MaríaMateria
Fibromyalgia Nitric oxide
Fecha
2021-01Referencia bibliográfica
Aguilar-Ferrándiz ME, Casas Barragán A, Tapia-Haro RM, Rus A, Molina F, Correa-Rodríguez M. Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with Fibromyalgia. J Therm Biol. 2021 Jan;95:102813. doi: 10.1016/j.jtherbio.2020.102813.
Resumen
Background: Fibromyalgia syndrome is defined as a complex disease, characterized by chronic widespread
musculoskeletal pain and other symptoms. The factors underlying physiopathology of fibromyalgia are not well
understood, complicating its diagnosis and management.
Objectives: To evaluate the peripheral vascular blood flow of the skin of the hands and the core body temperature
as indirect measures of sympathetic adrenergic activity of the nervous system and its relationship to nitric oxide
levels (NO) in women with fibromyalgia compared with healthy controls.
Methods: Forty-two women with fibromyalgia and 52 healthy women were enrolled in this observational pilot
study. We used infrared thermography of the hands and an infrared dermal thermometer to evaluate the peripheral vascular blood flow and tympanic and axillary core body temperature, respectively. We measured NO
levels using the ozone chemiluminescence-based method.
Results: Two-way analysis of covariance (ANCOVA) showed that the tympanic (P=0.002) and hand temperatures
were significantly higher in the patients with fibromyalgia than in the controls (P≤0.001). Significant associations were also found between serum NO levels and minimum temperatures at the dorsal center of the dominant
hand (β=-3.501; 95% confidence interval [CI] -6.805, ‑0.198; P= 0.038), maximum temperature (β=-5.594; 95%
CI ‑10.106, ‑1.081; P=0.016), minimum temperature (β=-4.090; 95% CI ‑7.905, ‑0.275; P=0.036), and mean
temperature (β=-5.519; 95% CI ‑9.933, ‑1.106; P=0.015) of the center of the palm of the non-dominant hand,
maximum temperature at the thenar eminence of the dominant hand (β=-5.800; 95% CI ‑10.508, ‑1.092;
P=0.017), and tympanic temperature (β=-9.321; 95% CI ‑17.974, ‑0.669; P=0.035) in the controls.
Conclusions: Our findings indicate that the women with fibromyalgia showed higher tympanic core body and
hand temperature than the healthy controls. Moreover, there were negative associations between hand peripheral vasodilation and NO in the healthy women but not in those with fibromyalgia, suggesting a dysfunction
of sympathetic cutaneous neural control.