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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/47249

Title: Photoacoustic molecular imaging for in vivo liver iron quantitation
Authors: Maccarinelli, Federica
Carmona Rodríguez-Acosta, Fernando
Regoni, Maria
Arosio, Paolo
Issue Date: 2016
Abstract: A recent study showed that ferritin is a suitable endogenous contrast agent for photoacoustic molecular imaging in cultured mammalian cells. We have therefore tested whether this imaging technique can be used for in vivo quantification of iron in mouse livers. To verify this hypothesis, we used multispectral optoacoustic tomography (MSOT) to image albino CD1 mice before and after experimental iron loading. Postmortem assays showed that the iron treatment caused a 15-fold increase in liver iron and a 40-fold increase in liver ferritin levels, while in vivo longitudinal analysis using MSOT revealed just a 1.6-fold increase in the ferritin/iron photoacoustic signal in the same animals. We conclude that MSOT can monitor changes in ferritin/iron levels in vivo, but its sensitivity is much lower than that of ex vivo iron assays.
Sponsorship: The work was partially supported by PRIN10-11 grant to P.A. F.M. was partially supported by a fellowship by Consorzio Interuniversitario Biotecnologie.
Publisher: Society of Photo-optical Instrumentation Engineers (SPIE)
Description: Maccarinelli, F.; et al. Photoacoustic molecular imaging for in vivo liver iron quantitation. Journal of Biomedical Optics 21(5): 056008 (2016). (Mar 1, 2016). DOI: http://dx.doi.org/10.1117/1.JBO.21.5.056008
Copyright 2017 Society of Photo Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, or modification of the contents of the publication are prohibited.
Keywords: Photoacoustic
Iron
Ferritin
Multispetral optoacoustic tomography
URI: http://hdl.handle.net/10481/47249
ISSN: 1083-3668
1560-2281
Citation: Maccarinelli, F.; et al. Photoacoustic molecular imaging for in vivo liver iron quantitation. Journal of Biomedical Optics 21(5): 056008 (2016). [http://hdl.handle.net/10481/47249]
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