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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/45149

Title: Antimicrobial activity of ProRoot MTA in contact with blood
Authors: Farrugia, C.
Baca García, Pilar
Camilleri, J.
Arias-Moliz, Teresa
Issue Date: 2017
Abstract: Dental materials based on Portland cement, which is used in the construction industry have gained popularity for clinical use due to their hydraulic properties, the interaction with tooth tissue and their antimicrobial properties. The antimicrobial properties are optimal in vitro. However in clinical use contact with blood may affect the antimicrobial properties. This study aims to assess whether antimicrobial properties of the Portland cement-based dental cements such as mineral trioxide aggregate (MTA) are also affected by contact with blood present in clinical situations. ProRoot MTA, a Portland cement-based dental cement was characterized following contact with water, or heparinized blood after 1 day and 7 days aging. The antimicrobial activity under the mentioned conditions was assessed using 3 antimicrobial tests: agar diffusion test, direct contact test and intratubular infection test. MTA in contact with blood was severely discoloured, exhibited an additional phosphorus peak in elemental analysis, no calcium hydroxide peaks and no areas of bacterial inhibition growth in the agar diffusion test were demonstrated. ProRoot MTA showed limited antimicrobial activity, in both the direct contact test and intratubular infection test. When aged in water ProRoot MTA showed higher antimicrobial activity than when aged in blood. Antimicrobial activity reduced significantly after 7 days. Further assessment is required to investigate behaviour in clinical situations.
Sponsorship: ERDF (Malta) for the financing of the testing equipment through the project: “Developing an Interdisciplinary Material Testing and Rapid Prototyping R&D Facility” (Ref. no. 012).
Publisher: Nature Publishing Group
Keywords: Biomedical materials
Microbiology techniques
Dental materials
ProRoot MTA
URI: http://hdl.handle.net/10481/45149
ISSN: 2045-2322
Citation: Farrugia, C.; et al. Antimicrobial activity of ProRoot MTA in contact with blood. Scientific Reports, 7: 41359 (2017). [http://hdl.handle.net/10481/45149]
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