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dc.contributor.authorFarrugia, C.es_ES
dc.contributor.authorBaca García, María Pilar es_ES
dc.contributor.authorCamilleri, J.es_ES
dc.contributor.authorArias-Moliz, Teresaes_ES
dc.date.accessioned2017-03-09T09:45:16Z
dc.date.available2017-03-09T09:45:16Z
dc.date.issued2017
dc.identifier.citationFarrugia, C.; et al. Antimicrobial activity of ProRoot MTA in contact with blood. Scientific Reports, 7: 41359 (2017). [http://hdl.handle.net/10481/45149]es_ES
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10481/45149
dc.description.abstractDental materials based on Portland cement, which is used in the construction industry have gained popularity for clinical use due to their hydraulic properties, the interaction with tooth tissue and their antimicrobial properties. The antimicrobial properties are optimal in vitro. However in clinical use contact with blood may affect the antimicrobial properties. This study aims to assess whether antimicrobial properties of the Portland cement-based dental cements such as mineral trioxide aggregate (MTA) are also affected by contact with blood present in clinical situations. ProRoot MTA, a Portland cement-based dental cement was characterized following contact with water, or heparinized blood after 1 day and 7 days aging. The antimicrobial activity under the mentioned conditions was assessed using 3 antimicrobial tests: agar diffusion test, direct contact test and intratubular infection test. MTA in contact with blood was severely discoloured, exhibited an additional phosphorus peak in elemental analysis, no calcium hydroxide peaks and no areas of bacterial inhibition growth in the agar diffusion test were demonstrated. ProRoot MTA showed limited antimicrobial activity, in both the direct contact test and intratubular infection test. When aged in water ProRoot MTA showed higher antimicrobial activity than when aged in blood. Antimicrobial activity reduced significantly after 7 days. Further assessment is required to investigate behaviour in clinical situations.en_EN
dc.description.sponsorshipERDF (Malta) for the financing of the testing equipment through the project: “Developing an Interdisciplinary Material Testing and Rapid Prototyping R&D Facility” (Ref. no. 012).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupen_EN
dc.subjectBiomedical materials en_EN
dc.subjectMicrobiology techniquesen_EN
dc.subjectDental materials en_EN
dc.subjectAntimicrobialen_EN
dc.subjectProRoot MTAen_EN
dc.titleAntimicrobial activity of ProRoot MTA in contact with blooden_EN
dc.typeinfo:eu-repo/semantics/articleen_EN
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen_EN
dc.identifier.doi10.1038/srep41359


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