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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/35583

Title: Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
Authors: Ortega, Francisco G.
Fernández-Baldo, Martín A.
Fernández, Jorge G.
Serrano Fernández, María José
Sanz, María I.
Díaz-Mochón, Juan J.
Lorente Acosta, José Antonio
Raba, J.
Issue Date: 2015
Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.
Sponsorship: Support from Universidad Nacional de San Luis, to the Agencia Nacional de Promoción Científica y Tecnológica, from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Argentina), and from GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, Granada, Spain are acknowledged.
Publisher: Dove Press
Keywords: Apoptosis
Biosynthesized silver nanoparticles
Breast cancer
Microbiological synthesis
URI: http://hdl.handle.net/10481/35583
ISSN: 1178-2013
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Ortega, F.G.; et al. Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast. International Journal of Nanomedicine, 10: 2021-2031 (2015). [http://hdl.handle.net/10481/35583]
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