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dc.contributor.authorOrtega, Francisco G.es_ES
dc.contributor.authorFernández-Baldo, Martín A.es_ES
dc.contributor.authorFernández, Jorge G.es_ES
dc.contributor.authorSerrano Fernández, María Josées_ES
dc.contributor.authorSanz, María I.es_ES
dc.contributor.authorDíaz-Mochón, Juan J.es_ES
dc.contributor.authorLorente Acosta, José Antonio es_ES
dc.contributor.authorRaba, J.es_ES
dc.date.accessioned2015-04-15T08:41:20Z
dc.date.available2015-04-15T08:41:20Z
dc.date.issued2015
dc.identifier.citationOrtega, F.G.; et al. Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast. International Journal of Nanomedicine, 10: 2021-2031 (2015). [http://hdl.handle.net/10481/35583]es_ES
dc.identifier.issn1178-2013
dc.identifier.urihttp://hdl.handle.net/10481/35583
dc.description.abstractIn the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.en_EN
dc.description.sponsorshipSupport from Universidad Nacional de San Luis, to the Agencia Nacional de Promoción Científica y Tecnológica, from Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Argentina), and from GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, Granada, Spain are acknowledged.en_EN
dc.language.isoenges_ES
dc.publisherDove Presses_ES
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Licensees_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es_ES
dc.subjectApoptosisen_EN
dc.subjectBiosynthesized silver nanoparticlesen_EN
dc.subjectBreast canceren_EN
dc.subjectMicrobiological synthesises_ES
dc.titleStudy of antitumor activity in breast cell lines using silver nanoparticles produced by yeasten_EN
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.2147/IJN.S75835


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