• español 
    • español
    • English
    • français
  • FacebookPinterestTwitter
  • español
  • English
  • français
Ver ítem 
  •   DIGIBUG Principal
  • 1.-Investigación
  • Departamentos, Grupos de Investigación e Institutos
  • Departamento de Educación Física y Deportiva
  • DEFD - Artículos
  • Ver ítem
  •   DIGIBUG Principal
  • 1.-Investigación
  • Departamentos, Grupos de Investigación e Institutos
  • Departamento de Educación Física y Deportiva
  • DEFD - Artículos
  • Ver ítem
JavaScript is disabled for your browser. Some features of this site may not work without it.

The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes

[PDF] Eynon_ACTN3.pdf (228.7Kb)
Identificadores
URI: http://hdl.handle.net/10481/30971
DOI: 10.1371/journal.pone.0043132
ISSN: 1932-6203
Exportar
RISRefworksMendeleyBibtex
Estadísticas
Ver Estadísticas de uso
Metadatos
Mostrar el registro completo del ítem
Autor
Eynon, Nir; Ruiz Ruiz, Jonatan; Femia Marzo, Pedro Jesús; Pushkarev, Vladimir P.; Cieszczyk, Pawel; Maciejewska-Karlwska, Agnieszka; Sawczuk, Marek; Dyatlow, Dmitry A.; Lekontsev, Evgeny V.; Kulikov, Leonid M.; Bishop, David J.; Lucía, Alejandro
Editorial
Public Library of Science (PLOS)
Materia
DNA isolation
 
Fast-twitch muscle fibers
 
Games
 
Genotyping
 
Human performance
 
Polymerase chain reaction
 
Spain
 
Variant genotypes
 
Fecha
2012
Referencia bibliográfica
Eynon, N.; et al. The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes. Plos One, 7(8): e43132 (2012). [http://hdl.handle.net/10481/30971]
Patrocinador
This work was supported by the Consejo Superior de Deportes (grant # 001/UPR10/12), Spanish Ministry of Science and Innovation (RYC-2010-05957), Fondo de Investigaciones Sanitarias (ref. # PS09/00194), the Polish Ministry of Science and Higher Education (grant#404166334), and the Ministry of Sport, Tourism and Youth Policy of the Russian Federation.
Resumen
The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34–0.48; P = 0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07–3.31; P = 0.028). In endurance athletes, the OR of a “world-class” competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08–12.94; P = 0.038) compared with those of a lower (“national”) competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance.
Colecciones
  • DEFD - Artículos

Mi cuenta

AccederRegistro

Listar

Todo DIGIBUGComunidades y ColeccionesPor fecha de publicaciónAutoresTítulosMateriaFinanciaciónPerfil de autor UGREsta colecciónPor fecha de publicaciónAutoresTítulosMateriaFinanciación

Estadísticas

Ver Estadísticas de uso

Servicios

Pasos para autoarchivoAyudaLicencias Creative CommonsSHERPA/RoMEODulcinea Biblioteca UniversitariaNos puedes encontrar a través deCondiciones legales

Contacto | Sugerencias