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The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes
dc.contributor.author | Eynon, Nir | |
dc.contributor.author | Ruiz Ruiz, Jonatan | |
dc.contributor.author | Femia Marzo, Pedro Jesús | |
dc.contributor.author | Pushkarev, Vladimir P. | |
dc.contributor.author | Cieszczyk, Pawel | |
dc.contributor.author | Maciejewska-Karlwska, Agnieszka | |
dc.contributor.author | Sawczuk, Marek | |
dc.contributor.author | Dyatlow, Dmitry A. | |
dc.contributor.author | Lekontsev, Evgeny V. | |
dc.contributor.author | Kulikov, Leonid M. | |
dc.contributor.author | Bishop, David J. | |
dc.contributor.author | Lucía, Alejandro | |
dc.date.accessioned | 2014-03-19T12:17:40Z | |
dc.date.available | 2014-03-19T12:17:40Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Eynon, N.; et al. The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes. Plos One, 7(8): e43132 (2012). [http://hdl.handle.net/10481/30971] | es_ES |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | doi: 10.1371/journal.pone.0043132 | |
dc.identifier.uri | http://hdl.handle.net/10481/30971 | |
dc.description | The PLOS ONE Staff (2014) Correction: The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes. PLoS ONE 9(3): e93165. doi: 10.1371/journal.pone.0093165 | es_ES |
dc.description.abstract | The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34–0.48; P = 0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07–3.31; P = 0.028). In endurance athletes, the OR of a “world-class” competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08–12.94; P = 0.038) compared with those of a lower (“national”) competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance. | es_ES |
dc.description.sponsorship | This work was supported by the Consejo Superior de Deportes (grant # 001/UPR10/12), Spanish Ministry of Science and Innovation (RYC-2010-05957), Fondo de Investigaciones Sanitarias (ref. # PS09/00194), the Polish Ministry of Science and Higher Education (grant#404166334), and the Ministry of Sport, Tourism and Youth Policy of the Russian Federation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.subject | DNA isolation | es_ES |
dc.subject | Fast-twitch muscle fibers | es_ES |
dc.subject | Games | es_ES |
dc.subject | Genotyping | es_ES |
dc.subject | Human performance | es_ES |
dc.subject | Polymerase chain reaction | es_ES |
dc.subject | Spain | es_ES |
dc.subject | Variant genotypes | es_ES |
dc.title | The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0043132 |