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Please use this identifier to cite or link to this item: http://hdl.handle.net/10481/29168

Title: Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
Authors: Sáenz-López, Pablo
Carretero, Rafael
Cózar Olmo, José Manuel
Romero Noguera, José María
Cantón, Julia
Vílchez, José Ramón
Tallada, Miguel
Garrido Torres-Puchol, Federico
Ruiz-Cabello, Francisco
Issue Date: 2008
Abstract: Background Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate cancer risk. The purpose of this study was to investigate whether single nucleotide polymorphisms of genes that lead to increased levels of pro-inflammatory cytokines and chemokines are associated with an increased prostate cancer risk.
Methods A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296 patients diagnosed with prostate cancer and in 311 healthy controls from the same area.
Results Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09–2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09–2.38). A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied. Finally, no overall association was found between prostate cancer risk and IL1-A or MCP-1 polymorphisms.
Conclusion Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
Sponsorship: This study was supported by grants from the Fondo de Investigaciones Sanitarias (FIS), Red Genomica del Cancer (RETIC RD 06/0020), Plan Andaluz de Investigacion (Group CTS 143), Consejeria Andaluz de Salud (SAS), Proyecto de Excelencia de Consejeria de Innovacion (CTS 695), Proyecto de investigacion I+D (SAF 2007-63262) in Spain; and from the Integrated European Cancer Immunotherapy project (OJ2004/C158, 518234).
Publisher: Biomed Central
Keywords: Case-control studies
Chemokine CCL2
Chemokine CCL5
Genetic predisposition to disease
Polymorphism
Prostatic neoplasms
Risk factors
Tumor necrosis factor-alpha
URI: http://hdl.handle.net/10481/29168
ISSN: 1471-2407
Rights : Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
Citation: Sáenz-López, P.; et al. Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer. BMC Cancer, 8: 382 (2008). [http://hdl.handle.net/10481/29168]
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