TY  - JOUR 
AU  - Sáenz-López, Pablo
AU  - Carretero, Rafael
AU  - Cózar Olmo, José Manuel
AU  - Romero Noguera, José María
AU  - Cantón, Julia
AU  - Vílchez, José Ramón
AU  - Tallada, Miguel
AU  - Garrido Torres-Puchol, Federico
AU  - Ruiz-Cabello, Francisco
PY  - 2008
SN  - 1471-2407
UR  - http://hdl.handle.net/10481/29168
AB  - Background
Inflammation has been implicated as an etiological factor in several human cancers, including prostate cancer. Allelic variants of the genes involved in inflammatory pathways are logical candidates as genetic determinants of prostate...
AB  - Methods
A case-control study design was used to test the association between prostate cancer risk and the polymorphisms TNF-A-308 A/G (rs 1800629), RANTES-403 G/A (rs 2107538), IL1-A-889 C/T (rs 1800587) and MCP-1 2518 G/A (rs 1024611) in 296...
AB  - Results
Diagnosis of prostate cancer was significantly associated with TNF-A GA + AA genotype (OR, 1.61; 95% CI, 1.09–2.64) and RANTES GA + AA genotype (OR, 1.44; 95% CI, 1.09–2.38). A alleles in TNF-A and RANTES influenced prostate cancer...
AB  - Conclusion
Our results and previously published findings on genes associated with innate immunity support the hypothesis that polymorphisms in proinflammatory genes may be important in prostate cancer development.
LA  - eng
PB  - Biomed Central
KW  - Case-control studies
KW  - Chemokine CCL2
KW  - Chemokine CCL5
KW  - Genetic predisposition to disease
KW  - Polymorphism
KW  - Prostatic neoplasms
KW  - Risk factors
KW  - Tumor necrosis factor-alpha
TI  - Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer
ER  -