TY  - JOUR 
AU  - Zou, Taisong
AU  - Risso, Valeria Alejandra
AU  - Gavira Gallardo, José Antonio
AU  - Sánchez Ruiz, José Manuel
AU  - Ozkan, S. Banu
PY  - 2015
UR  - https://hdl.handle.net/10481/86924
AB  - β-lactamases are produced by many modern bacteria as a mechanism of resistance toward β-lactam antibiotics, the most common antibiotics in use. β-lactamases, however, are ancient enzymes that originated billions of years ago. Recently, proteins...
LA  - eng
PB  - OXFORD UNIV PRESS
KW  - Protein dynamics and structure
KW  - Ancestral enzyme
KW  - Molecular dynamics
TI  - Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme
DO  - 10.1093/molbev/msu281
ER  -