TY  - JOUR 
AU  - Cheng, Kevin C. L.
AU  - Sánchez Luque, Francisco José
AU  - García Cañadas, Marta
AU  - García Pérez, José Luis
PY  - 2023
UR  - https://hdl.handle.net/10481/85914
AB  - Background

Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improves the...
LA  - eng
PB  - Springer Nature
KW  - Vitamin C
KW  - LINE-1
KW  - Embryonic stem cells
KW  - Mouse
KW  - Human
KW  - 2‑oxoglutarate‑dependent dioxygenases
KW  - DNA methylation
KW  - Histone methylation
KW  - Retrotransposition
TI  - Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
DO  - 10.1186/s13072-023-00514-6
ER  -