TY  - JOUR 
AU  - Ching López, Ana
AU  - Cervilla Ballesteros, Jorge A.
AU  - Rivera Sánchez, Margarita
AU  - Molina Rivas, Esther
AU  - McKenney, Kathryn Anne
AU  - Ruiz-Pérez, Isabel
AU  - Rodríguez Barranco, Miguel
AU  - Gutiérrez Martínez, Blanca
PY  - 2015
SN  - 1178-2021
UR  - http://hdl.handle.net/10481/39197
AB  - Background: Major depressive disorder (MDD) is a serious, and common psychiatric disorder worldwide. By the year 2020, MDD will be the second cause of disability in the world. The Granad∑p study is the first, to the best of our knowledge,...
AB  - Methods: A total of 711 community-based individuals participated in the Granad∑p study. All individuals were extensively assessed for clinical, psychological, sociodemographic, life style, and other environmental variables. A biological sample was...
AB  - Results: One SNP (rs623580) located in the tryptophan hydroxylase 1 gene (TPH1; chromosome 11), one intergenic variant (rs9526236) upstream of the 5-hydroxytryptamine receptor 2A gene (HTR2A; chromosome 13), and five polymorphisms (rs17689966,...
AB  - Conclusion: Although limited, perhaps due to insufficient sample size power, our results seem to support the notion that the hypothalamic–pituitary–adrenal and serotonergic systems are likely to be involved in the genetic susceptibility for MDD....
LA  - eng
PB  - Dove Medical Press
KW  - Genetic association analysis
KW  - Major depression
KW  - HPA axis
KW  - Serotonergic system
TI  - Epidemiological support for genetic variability at hypothalamic–pituitary–adrenal axis and serotonergic system as risk factors for major depression
DO  - 10.2147/NDT.S90369
ER  -