TY  - JOUR 
AU  - Nieto López, Francisco Rafael
AU  - Cendán Martínez, Cruz Miguel
AU  - Cañizares, Francisco J.
AU  - Cubero Sánchez, María Angustias
AU  - Vela, José M.
AU  - Fernández Segura, Eduardo
AU  - Baeyens Cabrera, José Manuel
PY  - 2014
SN  - 1744-8069
UR  - http://hdl.handle.net/10481/30783
AB  - Background
Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve mitochondrial alterations. The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone...
AB  - Results
Paclitaxel administration to wild-type (WT) mice produced cold- and mechanical-allodynia, and an increase in the frequency of swollen and vacuolated mitochondria in myelinated A-fibers, but not in C-fibers, of the saphenous nerve. Behavioral...
AB  - Conclusions
These results suggest that activation of the σ1R is necessary for development of the sensory nerve mitochondrial damage and neuropathic pain produced by paclitaxel. Therefore, σ1R antagonists might have therapeutic value for the...
LA  - eng
PB  - Biomed Central
KW  - Paclitaxel
KW  - Sigma-1 receptors
KW  - Chemotherapy-induced peripheral neuropathy
KW  - BD-1063
KW  - Mitochondria
KW  - Allodynia
KW  - Neuropathic pain
KW  - Sigma-1 receptor knockout mice
TI  - Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice
ER  -