Acute and cumulative benefits of Photobiomodulation for xerostomia: a systematic review and meta-analysis. Galiano-Castillo, Noelia Liu, Lizhou Lozano-Lozano, Mario Tumilty, Steve Cantarero-Villanueva, Irene Baxter, George David "This is the peer reviewed version of the following article: [Galiano-Castillo N, Liu L, Lozano-Lozano M, Tumilty S, Cantarero-Villanueva I, Baxter GD. Acute and cumulative benefits of Photobiomodulation for xerostomia: A systematic review and meta-analysis. Oral Dis. 2021Jul;27(5):1115-1126. doi: 10.1111/odi.13648. Epub 2020 Oct 10. PMID: 32964596.], which has been published in final form at [10.1111/odi.13648]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." The objective was to explore the effectiveness of photobiomodulation therapy for treating patients who suffer xerostomia and/or hyposalivation due to the most prevalent clinical diagnoses. We searched PubMed, Scopus, Web of Science, CINAHL, and Cochrane Library for randomised or clinical controlled trials published until 31 October 2019. Risk of bias assessment and meta-analysis were conducted using the Cochrane tools. A total of 274 records were retrieved and 11 met the inclusion criteria. Interventions whose parameters ranged between wavelengths of 790-830nm (infrared), 30-120mW of power, and an energy density below 30J/cm-2 were associated with improvements in xerostomia/hyposalivation. As for the assessment of methodological quality, 10 of the 11 articles included had a high risk of overall bias. Only 3 articles provided sufficient information to conduct a meta-analysis for quality of life, compared with placebo in patients with burning mouth syndrome, showing a standardised mean difference between groups from baseline of -0.90 (-1.48;-0.32). The present review and meta-analysis suggest that photobiomodulation therapy is an effective, non-invasive and safe approach in patients with xerostomia. However, despite the potential, it is not possible to reach a reliable consensus on the parameters to be used, and future studies should be conducted by standardising intervention protocols. 2024-01-29T12:54:12Z 2024-01-29T12:54:12Z 2021 info:eu-repo/semantics/article Galiano-Castillo N, Liu L, Lozano-Lozano M, Tumilty S, Cantarero-Villanueva I, Baxter GD. Acute and cumulative benefits of Photobiomodulation for xerostomia: A systematic review and meta-analysis. Oral Dis. 2021 Jul;27(5):1115-1126. doi: 10.1111/odi.13648. Epub 2020 Oct 10. PMID: 32964596. https://hdl.handle.net/10481/87509 10.1111/odi.13648 eng info:eu-repo/semantics/openAccess