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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/80370">
      <dc:title>Cell-Laden Marine Gelatin Methacryloyl Hydrogels Enriched with Ascorbic Acid for Corneal Stroma Regeneration</dc:title>
      <dc:creator>Alves, Ana L.</dc:creator>
      <dc:creator>Alaminos Mingorance, Miguel</dc:creator>
      <dc:subject>Marine biomaterials</dc:subject>
      <dc:subject>Gelatin</dc:subject>
      <dc:subject>Codfish</dc:subject>
      <dc:subject>GelMA</dc:subject>
      <dc:subject>Keratocytes</dc:subject>
      <dc:subject>Cornea</dc:subject>
      <dc:description>Corneal pathologies from infectious or noninfectious origin have a significant impact on the&#xd;
daily lives of millions of people worldwide. Despite the risk of organ rejection or infection, corneal&#xd;
transplantation is currently the only effective treatment. Finding safe and innovative strategies is the&#xd;
main goal of tissue-engineering-based approaches. In this study, the potential of gelatin methacryloyl&#xd;
(GelMA) hydrogels produced from marine-derived gelatin and loaded with ascorbic acid (as&#xd;
an enhancer of the biological activity of cells) was evaluated for corneal stromal applications. Marine&#xd;
GelMA was synthesized with a methacrylation degree of 75%, enabling effective photocrosslinking,&#xd;
and hydrogels with or without ascorbic acid were produced, encompassing human keratocytes. All&#xd;
the produced formulations exhibited excellent optical and swelling properties with easy handling as&#xd;
well as structural stability and adequate degradation rates that may allow proper extracellular matrix&#xd;
remodeling by corneal stromal cells. Formulations loaded with 0.5 mg/mL of ascorbic acid enhanced&#xd;
the biological performance of keratocytes and induced collagen production. These results suggest&#xd;
that, in addition to marine-derived gelatin being suitable for the synthesis of GelMA, the hydrogels&#xd;
produced are promising biomaterials for corneal regeneration applications.</dc:description>
      <dc:date>2023-03-03T09:48:32Z</dc:date>
      <dc:date>2023-03-03T09:48:32Z</dc:date>
      <dc:date>2023-01-04</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Alves, A.L... [et al.]. Cell-Laden Marine Gelatin Methacryloyl Hydrogels Enriched with Ascorbic Acid for Corneal Stroma Regeneration. Bioengineering 2023, 10, 62. [https://doi.org/10.3390/bioengineering10010062]</dc:identifier>
      <dc:identifier>https://hdl.handle.net/10481/80370</dc:identifier>
      <dc:identifier>10.3390/bioengineering10010062</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/4.0/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 4.0 Internacional</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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