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   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/72148">
      <dc:title>Lifestyle correlates of eight breast cancerrelated metabolites: a cross-sectional study within the EPIC cohort</dc:title>
      <dc:creator>His, Mathilde</dc:creator>
      <dc:creator>Sánchez Pérez, María José</dc:creator>
      <dc:subject>Metabolites</dc:subject>
      <dc:subject>Breast cancer</dc:subject>
      <dc:subject>Cross-sectional</dc:subject>
      <dc:subject>Lifestyle</dc:subject>
      <dc:subject>Anthropometry</dc:subject>
      <dc:description>This work was funded by the French National Cancer Institute (grant number 2015-166). Mathilde His' work reported here was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by the Fondation ARC.&#xd;
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The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC).&#xd;
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The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology-ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk (DOI 10.22025/2019.10.105.00004); C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (UK). The funders were not involved in designing the study; collecting, analyzing, or interpreting the data; or writing or submitting the manuscript for publication.</dc:description>
      <dc:description>Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to&#xd;
cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones,&#xd;
we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite&#xd;
(acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine,&#xd;
phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2).&#xd;
Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional&#xd;
analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as&#xd;
controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition&#xd;
cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with&#xd;
42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant&#xd;
associations were evaluated in a validation set (n = 786).&#xd;
Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34:&#xd;
2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and&#xd;
saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively&#xd;
associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively&#xd;
associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors&#xd;
examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive&#xd;
association with age was observed. Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and&#xd;
anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle&#xd;
correlates of the metabolites investigated.</dc:description>
      <dc:date>2021-12-21T08:20:49Z</dc:date>
      <dc:date>2021-12-21T08:20:49Z</dc:date>
      <dc:date>2021-12-10</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>His, M... [et al.]. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort. BMC Med 19, 312 (2021). [https://doi.org/10.1186/s12916-021-02183-2]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/72148</dc:identifier>
      <dc:identifier>10.1186/s12916-021-02183-2</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>BMC</dc:publisher>
   </ow:Publication>
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