<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/68721">
      <dc:title>Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer</dc:title>
      <dc:creator>Jiménez Luna, Cristina</dc:creator>
      <dc:creator>González Flores, Encarnación</dc:creator>
      <dc:creator>Ortiz Quesada, Raúl</dc:creator>
      <dc:creator>Martínez González, Luis Javier</dc:creator>
      <dc:creator>Antúnez Rodríguez, Alba</dc:creator>
      <dc:creator>Expósito Ruiz, Manuela</dc:creator>
      <dc:creator>Melguizo Alonso, Consolación</dc:creator>
      <dc:creator>Caba Pérez, Octavio</dc:creator>
      <dc:creator>Prados Salazar, José Carlos</dc:creator>
      <dc:subject>Metastatic colon cancer</dc:subject>
      <dc:subject>Biomarkers</dc:subject>
      <dc:subject>Angiogenesis</dc:subject>
      <dc:subject>Liquid biopsies</dc:subject>
      <dc:subject>Circulating mRNA</dc:subject>
      <dc:subject>Digital PCR</dc:subject>
      <dc:description>Genes involved in the angiogenic process have been proposed for the diagnosis and&#xd;
therapeutic response of metastatic colorectal cancer (CRC). This study aimed to investigate the value&#xd;
of PTGS2, JAG1, GUCY2C and PGF-circulating RNA as biomarkers in metastatic CRC. Blood cells&#xd;
and serum mRNA from 59 patients with metastatic CRC and 47 healthy controls were analyzed by&#xd;
digital PCR. The area under the receiver operating characteristic curve (AUC) was used to estimate&#xd;
the diagnostic value of each mRNA alone or mRNA combinations. A significant upregulation of the&#xd;
JAG1, PTGS2 and GUCY2C genes in blood cells and serum samples from metastatic CRC patients&#xd;
was detected. Circulating mRNA levels in the serum of all genes were significantly more abundant&#xd;
than in blood. The highest discrimination ability between metastatic CRC patients and healthy&#xd;
donors was obtained with PTGS2 (AUC of 0.984) and GUCY2C (AUC of 0.896) in serum samples.&#xd;
Biomarker combinations did not improve the discriminatory capacity of biomarkers separately.&#xd;
Analyzed biomarkers showed no correlation with overall survival or progression-free survival,&#xd;
but GUCY2C and GUCY2C/PTGS2 expression in serum correlated significantly with the response&#xd;
to antiangiogenic agents. These findings demonstrate that assessment of genes involved in the&#xd;
angiogenic process may be a potential non-invasive diagnostic tool for metastatic CRC and its&#xd;
response to antiangiogenic therapy.</dc:description>
      <dc:date>2021-05-25T12:30:06Z</dc:date>
      <dc:date>2021-05-25T12:30:06Z</dc:date>
      <dc:date>2021</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Jimenez-Luna, C.; González-Flores, E.; Ortiz, R.; Martínez-González, L.J.; Antúnez-Rodríguez, A.; Expósito-Ruiz, M.; Melguizo, C.; Caba, O.; Prados, J. Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer. J. Clin. Med. 2021, 10, 2248. https://doi.org/10.3390/jcm10112248</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/68721</dc:identifier>
      <dc:identifier>10.3390/jcm10112248</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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