The efficacy of three-dimensional conformal radiation therapy on pain and quality of life in patients with painful bone metastases: a prospective study Faris, Ayat Expósito Hernández, José Martínez Única, Antonio Arrebola Moreno, Juan Pedro Pérez Carrascosa, Francisco Miguel Guerrero, Rosario Tovar Gálvez, María Isabel AF, JE, and AM conceived and designed the study; all authors acquired the data; AF, JE, JP, and FM analyzed and interpreted the data; all authors drafted the manuscript; all authors critically revised the manuscript for important intellectual content; all authors gave approval of the version to be submitted; all authors agree to be accountable for all aspects of the work. Aim To evaluate the efficacy of radiation therapy in alleviating pain and improving the quality of life (QoL) with validated questionnaires in patients with painful bone metastases (BoM). Methods This prospective, observational study recruited 167 patients with painful BoM who were treated with palliative radiotherapy (PRT) from February 2015 to February 2018. After the first clinical assessment, the patients filled out specific questionnaires and underwent a fast radiotherapy treatment within 48 hours. The patients were followed up for eight weeks. Results The median age was 66.30 years. The most common primary cancer was lung cancer (31.1%). The most often prescribed scheme was 8 Gy in one fraction (70%). The patients experienced significant pain response and improved QoL compared with baseline, especially in the first two weeks after radiation. Overall, reduced pain and drug score were reported at two weeks of PRT in 68 (51.5%) and 37 (28%) of patients, respectively. Conclusions PRT is an effective treatment option for patients with painful BoM. 2020-11-25T10:08:21Z 2020-11-25T10:08:21Z 2020-06 info:eu-repo/semantics/article Faris, A., Expósito, J., Martínez-Única, A., Arrebola, J. P., Pérez-Carrascosa, F. M., Guerrero, R., & Tovar, I. (2020). The efficacy of three-dimensional conformal radiation therapy on pain and quality of life in patients with painful bone metastases: a prospective study. Croatian medical journal, 61(3), 215. [https://doi.org/10.3325/cmj.2020.61.215] http://hdl.handle.net/10481/64480 10.3325/cmj.2020.61.215 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Atribución-NoComercial-SinDerivadas 3.0 España Medicinska Naklada