Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents Jiménez López, Julia García Hevia, Lorena Melguizo Alonso, Consolación Prados Salazar, José Carlos Magnetic nanocomposites Magnetic Hyperthermia Combinatorial therapy 3D in vitro models Drug Delivery The development of nanotechnology-based solutions for cancer at a preclinical level advances at an astounding pace. So far, clinical translation of these new developments has not been able to keep the pace due to a range of different reasons. One of them is the mismatch between in vitro and in vivo results coming from the expected difference in complexity. To overcome this problem, extensive characterisation using advanced in vitro models can lead to stronger preliminary data to face in vivo tests. Here, a comprehensive in vitro validation of a combinatorial therapy nanoformulation against solid tumours is presented. The information extracted from the different in vitro models highlights the importance of advanced 3D models to fully understand the potential of this type of complex drugs. 2020-09-14T07:51:47Z 2020-09-14T07:51:47Z 2020-07-07 info:eu-repo/semantics/article Jiménez-López, J., García-Hevia, L., Melguizo, C., Prados, J., Bañobre-López, M., & Gallo, J. (2020). Evaluation of Novel Doxorubicin-Loaded Magnetic Wax Nanocomposite Vehicles as Cancer Combinatorial Therapy Agents. Pharmaceutics, 12(7), 637. [doi:10.3390/pharmaceutics12070637] http://hdl.handle.net/10481/63406 doi:10.3390/pharmaceutics12070637 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI