Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults Jurado Fasoli, Lucas Castillo, Manuel J. Amaro Gahete, Francisco José Dietary inflammatory index Aging Inflammation Klotho Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40–65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels ( B = 52.223, R2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults. 2020-05-05T11:48:37Z 2020-05-05T11:48:37Z 2020-01-21 info:eu-repo/semantics/article Jurado-Fasoli, L., Castillo, M. J., & Amaro-Gahete, F. J. (2020). Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults. Nutrients, 12(2), 281. http://hdl.handle.net/10481/61790 10.3390/nu12020281 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI