Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends Hernández Mesa, Maykel Ropartz, David García Campaña, Ana María Rogniaux, Hélène Dervilly Pinel, Gaud Le Bizec, Bruno Food quality Food composition Food process control Food authentication Food safety In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characterization of biomolecules (e.g., proteins, glycans, lipids, etc.) and, more recently, of small molecules (e.g., metabolites, xenobiotics, etc.). Following this trend, the interest in this technique is growing among researchers from different fields including food science. Several advantages are attributed to IMS when integrated in traditional liquid chromatography (LC) and gas chromatography (GC) mass spectrometry (MS) workflows: (1) it improves method selectivity by providing an additional separation dimension that allows the separation of isobaric and isomeric compounds; (2) it increases method sensitivity by isolating the compounds of interest from background noise; (3) and it provides complementary information to mass spectra and retention time, the so-called collision cross section (CCS), so compounds can be identified with more confidence, either in targeted or non-targeted approaches. In this context, the number of applications focused on food analysis has increased exponentially in the last few years. This review provides an overview of the current status of IMS technology and its applicability in different areas of food analysis (i.e., food composition, process control, authentication, adulteration and safety). 2020-04-22T11:44:27Z 2020-04-22T11:44:27Z 2019-07-25 info:eu-repo/semantics/article Hernández-Mesa, M., Ropartz, D., García-Campaña, A. M., Rogniaux, H., Dervilly-Pinel, G., & Le Bizec, B. (2019). Ion mobility spectrometry in food analysis: principles, current applications and future trends. Molecules, 24(15), 2706. http://hdl.handle.net/10481/61490 10.3390/molecules24152706 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI