Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging Villegas Aguilar, María del Carmen Fernández Ochoa, Álvaro Cádiz Gurrea, María de la Luz Pimentel Moral, Sandra Lozano Sánchez, Jesús Arráez Román, David Segura Carretero, Antonio Pleiotropic Phenolic compounds Chronic disorders Metabolites Bioactive compounds Oxidation Inflammation Aging The authors would like to thank to the Ministry of Science, Innovation and Universities (RTI2018-096724-B-C22). The author M.d.C.V.-A. is grateful acknowledges to the Ministry of Science, Innovation and Universities, University of Granada and AGR274 group for the contract (5450). Also, the authors are grateful to the University of Granada for a “Contrato Puente” postdoctoral contracts (Á.F.-O. and S.P.-M.) and a “Perfeccionamiento de Doctores” postdoctoral contract (M.d.l.L.C.-G.). Dietary phenolic compounds are considered as bioactive compounds that have effects in different chronic disorders related to oxidative stress, inflammation process, or aging. These compounds, coming from a wide range of natural sources, have shown a pleiotropic behavior on key proteins that act as regulators. In this sense, this review aims to compile information on the effect exerted by the phenolic compounds and their metabolites on the main metabolic pathways involved in energy metabolism, inflammatory response, aging and their relationship with the biological properties reported in high prevalence chronic diseases. Numerous in vitro and in vivo studies have demonstrated their pleiotropic molecular mechanisms of action and these findings raise the possibility that phenolic compounds have a wide variety of roles in different targets. 2020-03-25T09:18:55Z 2020-03-25T09:18:55Z 2020-01-29 info:eu-repo/semantics/article Villegas-Aguilar, M.C.; Fernández-Ochoa, Á.; Cádiz-Gurrea, M.L.; Pimentel-Moral, S.; Lozano-Sánchez, J.; Arráez-Román, D.; Segura-Carretero, A. Pleiotropic Biological Effects of Dietary Phenolic Compounds and their Metabolites on Energy Metabolism, Inflammation and Aging. Molecules 2020, 25, 596. [doi:10.3390/molecules25030596] http://hdl.handle.net/10481/60610 10.3390/molecules25030596 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI