Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community Hernández Jérez, Antonio Francisco Lozano Paniagua, David González Alzaga, Beatriz Kavvalakis, Matthaios Tzatzarakis, Manolis López Flores, Inmaculada Aguilar Garduño, Clemente Caparrós González, Rafael Arcángel Tsatsakis, Aristidis Lacasaña Navarro, Marina Pesticides DAPs Hair Urine Children Biomonitoring Levels of dialkylphosphate (DAP) metabolites were measured in hair and urine of children that lived close to intensively farmed areas of Almeria (Southeast Spain). The levels were used as proxies for exposure of these children to organophosphate pesticides (OPs). Determinants of exposure to DAPs were also examined. Urine and hair samples were collected from 222 children aged 3–11 years and information on lifestyle and dietary habits was collected from questionnaires administered to mothers. Urinary DAPs were analyzed by ultra-high performance liquid-chromatography coupled to triple-quadrupole tandem mass-spectrometry (UHPLC-QqQ-MS/MS) and hair DAPs by gas-chromatography coupled to mass spectrometry (GC–MS). Detection rates ranged from 21.8% for diethylphosphate (DEP) and diethylthiophosphate (DETP) to 35.9% for dimethylphosphate (DMP) in urine; and from 42.3% for DETP to 92.8% for DMP in hair. Diethyldithiophosphate (DEDTP) was detected in 0.5% of urine samples (one child), and in 26.6% of children's hair samples. A lack of correlation was observed for individual DAP metabolites and ΣDAPs between urine and hair samples, except for DEDTP. Urinary DAP levels of our child population were lower than those reported for children from other countries, including NHANES 1999–2000 data. 2019-11-21T11:49:50Z 2019-11-21T11:49:50Z 2019-07-27 info:eu-repo/semantics/article Hernández, A. F., Lozano-Paniagua, D., González-Alzaga, B., Kavvalakis, M. P., Tzatzarakis, M. N., López-Flores, I., ... & Lacasaña, M. (2019). Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community. Environment international, 131, 104997. http://hdl.handle.net/10481/58009 10.1016/j.envint.2019.104997 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier BV