<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/50255">
      <dc:title>Ion-modified nanoparticles induce different apatite formation in cervical dentine</dc:title>
      <dc:creator>Toledano Pérez, Manuel</dc:creator>
      <dc:creator>Toledano Osorio, Manuel</dc:creator>
      <dc:creator>Medina Castillo, Antonio Luis</dc:creator>
      <dc:creator>López López, Modesto Torcuato</dc:creator>
      <dc:creator>Sánchez Aguilera, Fátima</dc:creator>
      <dc:creator>Osorio Ruiz, Raquel</dc:creator>
      <dc:subject>Dentin</dc:subject>
      <dc:subject>Hypersensitivity</dc:subject>
      <dc:subject>Microscopy</dc:subject>
      <dc:subject>Remineralization</dc:subject>
      <dc:subject>TEM</dc:subject>
      <dc:subject>XRD</dc:subject>
      <dc:description>Aim: The aim of this research was to investigate if mineral and ultrastructure is modified when cervical dentin is treated with four different nanogels-based solutions for remineralizing purposes. Methodology: Experimental nanogels based on zinc, calcium and doxycycline-loaded polymeric nanoparticles were applied on citric acid etched dentin to facilitate the occlusion of tubules and the mineralization of the dentin surface. Dentin surfaces were studied by X-ray diffraction and transmission electron microscopy through selected area diffraction and bright-field imaging and selected area electron diffraction. Results: Crystals at the dentin surface were identified as hydroxyapatite with the highest crystallographic maturity and crystallite size in dentin treated with Zn-NPs based-gel. Texture increased in all samples from 24 h to 7 d, except in dentin surfaces treated with Zn-NPs gel. Polyhedral, plate-like and drop-like shaped apatite crystals constituted the bulk of minerals in dentin treated with Zn-NPs gel, after 7 d. Polymorphic, cubic and needle-like shaped crystals characterized minerals, more amorphous in dentin treated with Ca-NPs gel after 7 d than that found when Zn-NPs were applied. Doxycycline-NPs produced the smallest crystallites with poor crystallinity, maturity and chemical stability. Conclusions: Crystalline and amorphous phases of hydroxyapatite, described in both type of dentin treated with Zn-NPs as well as Ca-NPs gels, delayed the effect of erosion and contribute to improve the biomedical properties of cervical dentin after remineralization. Doxycycline-NPs based-gel are not recommended to treat dentin hypersensitivity.</dc:description>
      <dc:date>2018-04-16T12:31:14Z</dc:date>
      <dc:date>2018-04-16T12:31:14Z</dc:date>
      <dc:date>2018-02</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Toledano M, Toledano-Osorio M, Medina-Castillo AL, López-López MT, Aguilera FS, Osorio R. Ion-modified nanoparticles induce different apatite formation in cervical dentine. Int Endod J. 2018 Feb 28. doi: 10.1111/iej.12918. [Epub ahead of print] [http://hdl.handle.net/10481/50255]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/50255</dc:identifier>
      <dc:identifier>10.1111/iej.12918</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by-nc-nd/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución-NoComercial-SinDerivadas 3.0 España</dc:rights>
   </ow:Publication>
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