First synthesis of antitumoral dasyscyphin B Akhaouzan, Ali Fernández, Antonio Mansour, Ahmed I. Álvarez, Esteban Haidour, Ali Álvarez-Manzaneda, Ramón Chahboun Karimi, Rachid Álvarez-Manzaneda, Enrique Antitumoral Dasyscyphus niveus The first synthesis of dasyscyphin B, an antitumoral metabolite obtained from the ascomycete Dasyscyphus niveus, has been achieved starting from commercial abietic acid. The key steps of the synthetic sequence are the diastereoselective α-methylation of a ketoaldehyde, followed by an intramolecular aldol condensation and the further Diels–Alder cycloaddition of a dienol ester. The procedure reported will allow the synthesis of related metabolites functionalized in the A ring. 2013-09-05T10:09:23Z 2013-09-05T10:09:23Z 2013-07-23 info:eu-repo/semantics/article Akhaouzan, A.; et al. First synthesis of antitumoral dasyscyphin B. Organic and Biomolecular Chemistry, 11(36): 6176-6185 (2013). [http://hdl.handle.net/10481/27971] 1477-0520 1477-0539 doi: 10.1039/c3ob41290c PMID: 23928887 http://hdl.handle.net/10481/27971 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Royal Society of Chemistry