Could radiotherapy effectiveness be enhanced by electromagnetic field treatment? Artacho Cordón, Francisco Salinas Asensio, María del Mar Calvente, Irene Ríos Arrabal, Sandra León, Josefa Román-Marinetto, Elisa Olea Serrano, Nicolás Núñez, María Isabel Electromagnetic fields Cancer ELF magnetic exposure Radiotherapy Genotoxicity One of the main goals in radiobiology research is to enhance radiotherapy effectiveness without provoking any increase in toxicity. In this context, it has been proposed that electromagnetic fields (EMFs), known to be modulators of proliferation rate, enhancers of apoptosis and inductors of genotoxicity, might control tumor recruitment and, thus, provide therapeutic benefits. Scientific evidence shows that the effects of ionizing radiation on cellular compartments and functions are strengthened by EMF. Although little is known about the potential role of EMFs in radiotherapy (RT), the radiosensitizing effect of EMFs described in the literature could support their use to improve radiation effectiveness. Thus, we hypothesized that EMF exposure might enhance the ionizing radiation effect on tumor cells, improving the effects of RT. The aim of this paper is to review reports of the effects of EMFs in biological systems and their potential therapeutic benefits in radiotherapy. 2013-07-23T07:37:48Z 2013-07-23T07:37:48Z 2013-07 info:eu-repo/semantics/article Artacho-Cordón, F.; et al. Could radiotherapy effectiveness be enhanced by electromagnetic field treatment?. International Jorunal of Molecular Sciences, 14(7): 14974-14995 (2013). [http://hdl.handle.net/10481/27777] 1422-0067 doi: 10.3390/ijms140714974 http://hdl.handle.net/10481/27777 eng http://creativecommons.org/licenses/by-nc-nd/3.0/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License MDPI