Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis
Metadatos
Mostrar el registro completo del ítemAutor
Ortigosa Palomo, Alba; Fuentes-Ríos, David; Quiñonero Muñoz, Francisco José; Melguizo Alonso, Consolación; Ortiz Quesada, Raúl; López Romero, Juan Manuel; Prados Salazar, José CarlosEditorial
Wiley
Materia
African ginger apoptosis cytotoxic reactive oxygen species siphonochilone
Fecha
2024-05-14Referencia bibliográfica
Ortigosa-Palomo A, Fuentes-Ríos D, Quiñonero F, Melguizo C, Ortiz R, López- Romero JM, Prados J. Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis. Environ Toxicol. 2024 May 14. doi: 10.1002/tox.24308. Epub ahead of print. PMID: 38742918.
Resumen
Plants provide a wide array of compounds that can be explored for potential anticancer
properties. Siphonochilone, a furanoterpene that represents one of the main
components of the African plant Siphonochilus aethiopicus, shows numerous health
benefits. However, to date, its antiproliferative properties have not been tested. The
aim of this study was to analyze the cytotoxic effects of siphonochilone on a panel of
cancer cell lines and its underlying mechanism of action. Our results demonstrated
that siphonochilone exhibited significant cytotoxic effects on pancreatic, breast, lung,
colon, and liver cancer cell lines showing a IC50 ranging from 22 to 124 μM at 72 h
of treatment and highlighting its cytotoxic effect against MCF7 and PANC1 breast
and pancreas cancer cell lines (22.03 and 39.03 μM, respectively). Cell death in these
tumor lines was mediated by apoptosis by the mitochondrial pathway, as evidenced
by siphonochilone-induced depolarization of the mitochondrial membrane potential.
In addition, siphonochilone treatment involves the generation of reactive oxygen
species that may contribute to apoptosis induction. In this work, we described for
the first time the cytotoxic properties of siphonochilone and provided data about the
molecular processes of cell death. Although future studies will be necessary, our
results support the interest in this molecule in relation to their clinical application in
cancer, and especially in breast and pancreatic cancer.