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Post-antibiotic effect of three quinolones against gram negative isolates from urine
dc.contributor.author | Alados, J.C. | |
dc.contributor.author | Gutiérrez Fernández, José | |
dc.contributor.author | Garcia, F. | |
dc.contributor.author | Liebana, J. | |
dc.contributor.author | Piédrola Angulo, Gonzalo | |
dc.date.accessioned | 2024-05-06T08:24:56Z | |
dc.date.available | 2024-05-06T08:24:56Z | |
dc.date.issued | 1990-10 | |
dc.identifier.citation | Alados JC, Gutierrez J, Garcia F, Liebana J, Piedrola G. Post-antibiotic effect of three quinolones against gram negative isolates from urine. Med Lab Sci. 1990 Oct;47(4):272-7. | es_ES |
dc.identifier.other | PMID: 2283929 | |
dc.identifier.uri | https://hdl.handle.net/10481/91412 | |
dc.description.abstract | he post-antibiotic effect (PAE) is defined as the bacterial growth suppression which persists after a limited exposure to an antimicrobial agent. The PAE and the bactericidal effect of the quinolones ciprofloxacin, norfloxacin and nalidixic acid have been studied against several urinary isolates of Gram-negative bacteria. The PAE was determined after one hour's exposure to the antimicrobial agent using an initial inoculum of 10(5) to 10(6) cfu/ml; the drug was rapidly removed by a 10(-2) dilution technique in antibiotic-free medium. When ciprofloxacin was used at four times its MIC the PAEs were 1.37 +/- 0.09; 2.45 +/- 0.63 and 2.86 +/- 0.15 h against Esch. coli, Klebs. pneumoniae and Pseudomonas aeruginosa, respectively. We found lower values for norfloxacin under the same conditions, and nalidixic acid did not induce a significative PAE. These results could support changes in dosing intervals of norfloxacin and ciprofloxacin, with possibly greater intervals between doses. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Med Lab Sci . | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Post-antibiotic effect of three quinolones against gram negative isolates from urine | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |