Permeation Protection by Waterproofing Mucosal Membranes
Metadatos
Afficher la notice complèteAuteur
Coderch, Luisa; Alonso, Cristina; Calpena, Ana Cristina; Pérez García, María Luisa; Clares Naveros, Beatriz; Ramos, Anderson; Martí, MeritxellEditorial
MDPI
Materia
Mucosa Protection Permeability
Date
2023-11-29Referencia bibliográfica
Coderch, L.; Alonso, C.; Calpena, A.C.; Pérez-García, M.L.; Clares-Naveros, B.; Ramos, A.; Martí, M. Permeation Protection by Waterproofing Mucosal Membranes. Pharmaceutics 2023, 15, 2698. https://doi.org/10.3390/pharmaceutics15122698
Patrocinador
Consejo Superior de Investigaciones Científicas “Modificación de la mucosa como protección frente al SARS-CoV-2” (CSIC-COV19-130)Résumé
The permeability of the oral or nasal mucosa is higher than that of the skin. Mucosa permeability
depends mainly on the thickness and keratinization degree of the tissues. Their permeability
barrier is conditioned by the presence of certain lipids. This work has the main aim of reinforcing the
barrier effect of oral mucosa with a series of formulations to reduce permeation. Transmembrane
water loss of different formulations was evaluated, and three of them were selected to be tested on
the sublingual mucosa permeation of drugs. Caffeine, ibuprofen, dexamethasone, and ivermectin
were applied on porcine skin, mucosa, and modified mucosa in order to compare the effectiveness of
the formulations. A similar permeation profile was obtained in the different membranes: caffeine
> ibuprofen~dexamethasone > ivermectin. The most efficient formulation was a liposomal formulation
composed of lipids that are present in the skin stratum corneum. Impermeability provided
by this formulation was notable mainly for the low-molecular-weight compounds, decreasing their
permeability coefficient by between 40 and 80%. The reinforcement of the barrier function of mucosa
provides a reduction or prevention of the permeation of different actives, which could be extrapolated
to toxic compounds such as viruses, contaminants, toxins, etc.