From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin
Metadatos
Mostrar el registro completo del ítemAutor
Fernández Martínez, José; Ramírez Casas, Yolanda; Yang, Yang; Aranda Martínez, Paula; Martínez Ruiz, Laura; Escames Rosa, Germaine; Acuña Castroviejo, DaríoEditorial
MDPI
Materia
Aging Chronodisruption Clock genes
Fecha
2023-12-12Referencia bibliográfica
Fernández-Martínez, J.; Ramírez-Casas, Y.; Yang, Y.; Aranda-Martínez, P.;Martínez-Ruiz, L.; Escames, G.; Acuña-Castroviejo, D. From Chronodisruption to Sarcopenia: The Therapeutic Potential ofMelatonin. Biomolecules 2023, 13, 1779. https://doi.org/10.3390/biom13121779
Patrocinador
Instituto de Salud Carlos III, grant numbers PI19-01372 and CB/10/00238; FPU fellowship from the Ministerio de Universidades, Spain; PFIS fellowship from the Instituto de Salud Carlos IIIResumen
Sarcopenia is an age-related condition that involves a progressive decline inmusclemass and
function, leading to increased risk of falls, frailty, andmortality. Although the exactmechanisms are not
fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial
capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age
may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there
is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may
delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating
sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on
mitochondria and organelle, where it is synthesized and crucial in aging skeletal muscle, further
highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with
special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with
melatonin, which is proposed as a potential therapy against sarcopenia.