Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma
Metadatos
Afficher la notice complèteAuteur
González Moles, Miguel Ángel; Gutiérrez Fernández, José; Rodríguez, M. J.; Ruiz-Avila, I.; Rodríguez-Archilla, AlbertoEditorial
Wiley
Materia
Epstein-Barr virus Latent membrane protein-1 Oral squa-mous cell carcinoma
Date
2002-03Referencia bibliográfica
Gonzalez-Moles MA, Gutierrez J, Rodriguez MJ, Ruiz-Avila I, Rodriguez-Archilla A. Epstein-Barr virus latent membrane protein-1 (LMP-1) expression in oral squamous cell carcinoma. Laryngoscope. 2002 Mar;112(3):482-7. https://doi.org/10.1097/00005537-200203000-00014
Résumé
Objectives: Epstein-Barr virus (EBV) is frequently associated with malignant cell transformation through the action of the oncoprotein latent membrane protein-1 (LMP-1). The present study aimed to determine the presence of EBV in oral squamous cell carcinomas (OSCCs) and the expression of LMP-1 in neoplastic cells of EBV-positive OSCCs.
Study design/methods: In a retrospective study of 78 OSCCs, we investigated the presence of the DNA of EBV by polymerase chain reaction, the expression of the oncoprotein LMP-1 by immunohistochemistry, and the presence of EBV-encoded RNA (EBER) by in situ hybridization.
Results: EBV DNA was detected in 19.2% of the cases. Expression of LMP-1 in neoplastic cells was found in 85.7% of the EBV-positive OSCCs. EBV presence was significantly more frequent (P <.05) in OSCCs localized on the lateral tongue. EBV-positive OSCCs more frequently presented (P <.05) greater nuclear atypia.
Conclusion: EBV can appear in latent form in OSCC and express its main oncoprotein, LMP-1.