Silk fibroin nanoparticles as biocompatible nanocarriers of a novel light-responsive CO-prodrug

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URI: https://hdl.handle.net/10481/88191
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Author
Jiménez-Amezcua, Ignacio; Carmona Fernández, Francisco Jesús; Romero García, Ignacio; Quirós Olozábal, Miguel; Cenis, Jose L; Lozano Pérez, A. Abel; Rodríguez Maldonado, Carmen; Barea Martínez, Elisa María
Editorial
Royal Society of Chemistry
Date
2018-07-01
Referencia bibliográfica
Published version: Dalton Trans., 2018,47, 10434-10438. DOI: 10.1039/C8DT02125B
Sponsorship
The Spanish Ministry of Economy and Competitivity, the UE FEDER Program (CTQ2017-84692-R), University of Granada (C. R. Maldonado, Reincorporación Plan Propio, I. Romero-García, Beca de Iniciación a la Investigación Plan Propio), and the ERDF/FEDER Operative Programme of the Region of Murcia (Project No. 14-20-01) are gratefully acknowledged for generous funding. This study was partially supported by the “Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente” (University of Granada). The research contract of Dr A. Abel Lozano-Pérez was partially supported (80%) by the ERDF/FEDER Operative Programme of the Region of Murcia (Project No. 14-20-01). The authors also thank Prof. Meseguer-Olmo and Dr M. J. Yáñez-Gascón (UCAM, Murcia, Spain) for their help during FESEM image acquisition.
Abstract
[Mn(CO)3(2,2’-bipyridine)(PPh3)](ClO4) (1), a novel photoactive CO- releasing molecule, has been prepared and fully characterized. Besides, silk fibroin nanoparticles (SFNs) have been used, for the first time, as vehicles of 1 leading to the hybrid material 1@SFNs that shows an enhanced CO-delivery.
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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