Intracellular delivery of a catalytic organometallic complex

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URI: https://hdl.handle.net/10481/87343
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Auteur
Indrigo, Eugenio; Clavadetscher, Jessica; Chankeshwara, Sunay V.; Megía Fernández, Alicia; Lilienkampf, Annamaria; Bradley, Mark
Editorial
The Royal Society of Chemistry
Materia
Bioorthogonal
 
Palladium
 
Profluorophore
 
Cell-penetrating peptide
 
Date
2017
Referencia bibliográfica
Chem Commun 2017, 53, 6712-6715
Résumé
A homogeneous carbene-based palladium catalyst was conjugated to a cell-penetrating peptide, allowing intracellular delivery of catalytically active Pd complexes that demonstrated bioorthogonal activation of a profluorophore within prostate cancer cells.
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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