Vinyl sulfone: a versatile function for simple bioconjugation and immobilization

Identificadores
URI: https://hdl.handle.net/10481/87209
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Auteur
Morales Sanfrutos, Julia; López Jaramillo, Francisco Javier; Ortega Muñoz, Mariano; Megía Fernández, Alicia; Pérez Balderas, Francisco Manuel; Hernández Mateo, Fernando; Santoyo González, Francisco
Editorial
The Royal Society of Chemistry
Materia
Vinyl sulfone
 
Bioconjugation
 
Immobilization
 
Date
2010
Referencia bibliográfica
Org Biomol Chem 2010, 8, 667-675
Patrocinador
Financial Support was provided by Direccion General de Investigacion Cientıfica y Tecnica (DGICYT) (CTQ2008-01754) ´and Junta de Andalucıa (P07-FQM-02899). J. M.-S. thanks the University of Granada for a research contract (Programa Puente). A. M.-F. thanks the Spanish Ministerio de Educacion for a research fellowship (FPU)
Résumé
The easy functionalization of tags and solid supports with the vinyl sulfone function is a valuable tool in omic sciences that allows their coupling with the amine and thiol groups present in the proteogenic residues of proteins, in mild and green conditions compatible with their biological function.
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