Basolateral amygdala lesions attenuate safe taste memory-related c-fos expression in the rat perirhinal cortex
Metadatos
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Elsevier
Materia
Attenuation of neophobia Amygdala Fos Inmediate early gene Learning Memory Perirhinal cortex Rat Taste
Date
2012Referencia bibliográfica
Published version: https://doi.org/10.1016/j.bbr.2012.02.038
Patrocinador
HUM 02763 (Junta de Andalucía. Spain); PSIC2008-03933, PSIC2011-23702 (MICINN. Spain)Résumé
Previous results indicated that damage and pharmacological inactivation of the
basolateral amygdala (BLA) interfere with the attenuation of taste neophobia. A similar
disruption of safe taste memories formation induced by the inhibition of protein
synthesis in the perirhinal cortex (PRh) has been reported. Thus, we have assessed the
effect of bilateral BLA neurotoxic lesions on PRh activity after novel and familiar taste
exposure. Wistar male rats with NMDA lesions of the BLA and SHAM-operated received
two consecutive exposures to a 3% cider vinegar solution. Fos-like immunoreactivity
(FLI) was examined as a marker of neuronal activity in PRh. As expected the BLA lesioned
group showed no evidence of neophobia attenuation. A similar number of PRh Fos-positive cells were found in SHAM and BLA groups exposed to the novel taste solution.
However, the BLA-lesioned group exhibited a lower number of Fos stained cells than the
SHAM-lesioned group after being exposed to the familiar taste solution. This supports
the notion of BLA and PRh as components of a neural circuit involved in safe taste
recognition memory and suggests a role of PRh in various forms of recognition memory.