One-Pot Three-Component Click Reaction of Cyclic Sulfates and Cyclic Sulfamidates
Metadata
Show full item recordAuthor
Megía Fernández, Alicia; Ortega Muñoz, Mariano; Hernández Mateo, Fernando; Santoyo González, FranciscoEditorial
Wiley
Materia
Click chemistry Cyclic sulfamidates Cyclic sulfates
Date
2012Referencia bibliográfica
Advanced Synthesis & Catalysis (2012) 354, 1797- 1803
Sponsorship
Direccion General de Investigacion Cientıfica y Tecnica (DGICYT) (CTQ2008-01754); Junta de Andalucia (P07-FQM-02899); Programa Puente Plan Propio UGRAbstract
A one-pot, three-component methodology involving tandem azidation and click copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) of cyclic sulfates or cyclic sulfamidates in the presence of sodium azides and alkynes is reported. The developed protocol takes also advantage of the concomitant use of microwave (MW) irradiation and heterogeneous catalysis. The protocol allows the fast and efficient preparation of (alkyl sulfate)- and (alkyl sulfamidate)-1H-1,2,3-triazoles in a simple manner.