Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory
Metadatos
Mostrar el registro completo del ítemEditorial
Elsevier
Materia
Rat Hippocampus Taste Memory Attenuation of neophobia Dopamine
Fecha
2021Referencia bibliográfica
Published version: Grau Perales, A. B. Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory. Behavioural Brain Research Volume 409, 9 July 2021, 113320. [https://doi.org/10.1016/j.bbr.2021.113320]
Patrocinador
MINECO. Spain PSI2017-86381-P; MECD, Spain FPU14/01531Resumen
Taste recognition memory is evident in rodents because the initial neophobia to novel tastes attenuates
across exposures as the taste becomes familiar and safe. This attenuation of taste neophobia (AN) is context-dependent and an auditory background change could induce the recovery of the neophobic response. The AN
auditory context-dependency requires the hippocampal integrity but the neurochemical mechanisms
underlying the interaction with the taste memory circuit remain unexplored. We have applied pharmacological
intervention by 6-hidroxydopamine (6-OHDA) hippocampal lesion for assessing the role of catecholamines in
the hippocampal system to Wistar rats that drank a novel 3% vinegar solution for several consecutive days.
Additionally, we manipulated the auditory background as a context that could either change or remain
constant across all the drinking sessions. We found that a disruption of the context-dependent AN was induced
by intracerebral administration of 6-OHDA targeted to the ventral CA1 hippocampus (vCA1). We conclude
that the ability of the auditory context to modulate taste recognition memory involves the catecholaminergic
activity in the ventral hippocampal circuit for the proper acquisition of safe taste memory.