Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta-analysis
Metadatos
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Kouiti, Malak; Castillo-Hermoso, María Ángeles; Youlyouz-Marfak, Ibtissam; Saeed Khan, Khalid; Thangaratinam, Shakila; Olmedo-Requena, Rocío; Zamora, Javier; Jiménez-Moléon, José JuanEditorial
Wiley
Materia
Exposure Gestational diabetes mellitus Meta-analysis Persistent organic pollutants Risk factor Systematic review
Date
2023-12-04Referencia bibliográfica
Kouiti M, Castillo-Hermoso MÁ, Youlyouz-Marfak I, Khan KS, Thangaratinam S, Olmedo-Requena R, et al. Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta-analysis. BJOG. 2023;00:1–10. https://doi.org/10.1111/1471-0528.17725
Patrocinador
Funding for open access charge: Universidad de Granada/CBUARésumé
Background: Findings related to the association between persistent organic pollut-
ants (POPs) and gestational diabetes mellitus (GDM) are inconclusive.
Objectives: To estimate the strength of the association between POP exposure and
GDM in a systematic review with meta-analysis.
Search strategy: MEDLINE, Scopus and Web of Science were searched until July
2023.
Selection criteria: Cohort and case–control studies analysing the association be-
tween POPs and GDM.
Data collection and analysis: We assessed the risk of bias using the Quality in
Prognosis Studies scale (QUIPS). Standardised mean differences were pooled using
random-effect models.
Main results: Sixteen articles including 12 216 participants were selected. The risk of
bias was high in four articles (25%), moderate in 11 (68.75%) and low in one (6.25%).
Small mean difference between GDM cases and controls was observed for PFHpA
(0.26, 95% confidence interval [CI] 0.1–0.35, I2 = 0.0%), PCB180 (0.37, 95% CI 0.19–0.56;
I2 = 25.3%), BDE47 (0.23, 95% CI 0.0–0.45, I2 = 0%), BDE99 (0.36, 95% CI 0.14–0.59;
I2 = 0%), BDE100 (0.42, 95% CI 0.19–0.64; I2 = 0%) and HCB (0.22, 95% CI 0.01–0.42,
I2 = 39.6%). No considerable difference was observed for the rest of POPs.
Conclusion: Small mean differences between GDM cases and controls were ob-
served for some POPs. However, evidence shows mostly moderate quality and results
were heterogeneous. Improved research methodology is needed to assess POPs and
GDM risk.