Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models
Metadata
Show full item recordEditorial
Elsevier
Materia
Chemotherapy-induced peripheral neuropathy Chemotherapy-induced peripheral neurotoxicity Gait analysis Animal models Sensory ataxia Physical therapy Cat Walk™ Neuropathy
Date
2023-10-15Referencia bibliográfica
M. Lopez-Garzon et al. Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models. Brain Research Bulletin 203 (2023) 110769. [https://doi.org/10.1016/j.brainresbull.2023.110769]
Sponsorship
Instituto de Salud Carlos III FI19/00230, MV22/00095Abstract
Gait analysis could be used in animal models as an indicator of sensory ataxia due to chemotherapy-induced peripheral neurotoxicity (CIPN). Over the years, gait analysis in in vivo studies has evolved from simple observations carried out by a trained operator to computerised systems with machine learning that allow the quantification of any variable of interest and the establishment of algorithms for behavioural classification. However, there is not a consensus on gait analysis use in CIPN animal models; therefore, we carried out a systematic review. Of 987 potentially relevant studies, 14 were included, in which different methods were analysed (observation, footprint and CatWalk™). We presented the state-of-the-art of possible approaches to analyse sensory ataxia in rodent models, addressing advantages and disadvantages of different methods available. Semi-automated methods may be of interest when preventive or therapeutic strategies are evaluated, also considering their methodological simplicity and automaticity; up to now, only CatWalk™ analysis has been tested. Future studies should expect that CIPN-affected animals tend to reduce hind paw support due to pain, allodynia or loss of sensation, and an increase in swing phase could or should be observed. Few available studies documented these impairments at the last time point, and only appeared later on respect to other earlier signs of CIPN (such as altered neurophysiological findings). For that reason, gait impairment could be interpreted as late repercussions of loss of sensory.