Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers
Metadatos
Afficher la notice complèteAuteur
Pérez Regalado, Sergio; León, Josefa; Padial Puche, Paulino; Benavente Bardera, Cristina; Puentes Pardo, Jose D.; Almeida, Filipa; Feriche Fernández-Castanys, María BelénEditorial
Springer Nature
Materia
Hypoxia Resistance training Altitude Inflammation Cytokines
Date
2023-10-11Referencia bibliográfica
Pérez-Regalado, S., León, J., Padial, P. et al. Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers. Pflugers Arch - Eur J Physiol (2023). [https://doi.org/10.1007/s00424-023-02868-y]
Patrocinador
Universidad de Granada/CBUA This research was funded by the Spanish Ministry of Science; Innovation and Universities (grant number PGC2018-097388-B-I00-MCI/AEI/FEDER, UE); FEDER/Junta de Andalucía-Ministry of Economic Transformation; Industry, Knowledge and Universities (grant number B-CTS-374-UGR20)Résumé
The intensification of the stress response during resistance training (RT) under hypoxia conditions could trigger unwanted effects that compromise muscle health and, therefore, the ability of the muscle to adapt to longer training periods. We examined the effect of acute moderate terrestrial hypoxia on metabolic, inflammation, antioxidant capacity and muscle atrophy biomarkers after a single RT session in a young male population. Twenty healthy volunteers allocated to the normoxia (N < 700 m asl) or moderate altitude (HH = 2320 m asl) group participated in this study. Before and throughout the 30 min following the RT session (3 × 10 reps, 90 s rest, 70% 1RM), venous blood samples were taken and analysed for circulating calcium, inorganic phosphate, cytokines (IL-6, IL-10 and TNF-α), total antioxidant capacity (TAC) and myostatin. Main results displayed a marked metabolic stress response after the RT in both conditions. A large to very large proportional increase in the adjusted to pre-exercise change of inflammatory and anti-inflammatory markers favoured HH (serum TNF-α [ES = 1.10; p = 0.024] and IL-10 [ES = 1.31; p = 0.009]). The exercise produced a similar moderate increment of myostatin in both groups, followed by a moderate non-significant reduction in HH throughout the recovery (ES = − 0.72; p = 0.21). The RT slightly increased the antioxidant response regardless of the environmental condition. These results revealed no clear impact of RT under acute hypoxia on the metabolic, TAC and muscle atrophy biomarkers. However, a coordinated pro/anti-inflammatory response balances the potentiated effect of RT on systemic inflammatio