Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study
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Gálvez Ontiveros, Yolanda; Moscoso Ruiz, Inmaculada; Almazán Fernández de Bobadilla, Laura; Monteagudo Sánchez, Celia; Rodrigo Conde Salazar, Lourdes T.; Zafra Gómez, Alberto; Rivas Velasco, Ana MaríaEditorial
Frontiers
Materia
Overweight and obesity Childhood obesity Obesogens BPA and analogs Biological samples
Date
2023-08-14Referencia bibliográfica
Gálvez-Ontiveros Y, Moscoso-Ruiz I, Almazán Fernández de Bobadilla V, Monteagudo C, Giménez-Martínez R, Rodrigo L, Zafra-Gómez A and Rivas A (2023) Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study. Front. Nutr. 10:1226820. [doi: 10.3389/fnut.2023.1226820]
Sponsorship
FEDER-Consejería de Salud y Familias’ of the Junta de Andalucía PE-0250-2019Abstract
Introduction: A growing number of studies link the increase in overweight/
obesity worldwide to exposure to certain environmental chemical pollutants that
display obesogenic activity (obesogens). Since exposure to obesogens during
the first stages of life has been shown to have a more intense and pronounced
effect at lower doses, it is imperative to study their possible effects in childhood.
The objective here was to study the association of Bisphenol A (BPA) and 11 BPA
analogs in children, using three biological matrices (nails, saliva and urine), and
overweight and obesity (n = 160).
Methods: In this case–control study, 59 overweight/obese children and 101
controls were included. The measuring of Bisphenols in the matrices was carried
out by ultra-high performance liquid chromatography coupled with triple
quadrupole tandem mass spectrometry (UHPLC-MS/MS). Logistic regression
was used to study the association between overweight/obesity and Bisphenol
exposure.
Results: The results suggested that BPF in nails is associated with overweight/
obesity in children (OR:4.87; p = 0.020). In saliva, however, the highest detected
concentrations of BPAF presented an inverse association (OR: 0.06; p = 0.010)
with overweight/obesity. No associations of statistical significance were detected
between exposure to BPA or its other analogs and overweight/obesity in any of
the biological matrices.